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KMID : 0359920070260030311
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Korean Journal of Nephrology
2007 Volume.26 No. 3 p.311 ~ p.319
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Angiopoietins in Diabetic Nephropathy
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Lee Eun-Young
Gil Hyo-Wook
Yang Jong-Oh
Koh Jang-Hyun
Chung Choon-Hee
Hong Sae-Yong
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Abstract
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Purpose : It has been reported that angiopoietins and Tie-2 receptor play an important role in the maintenance of glomerular filtration barrier in various glomerulonephritis models. We studied the role of angiopoietins on renal injury in diabetes.
Methods : In this study, we examined the changes of angiopoietin-1, angiopoietin-2, Tie-2 receptor, and nephrin expression in the experimental diabetic nephropathy and also determined whether these changes were modified by renoprotective intervention by angiotensin II receptor blocker, α-lipoic acid, and peroxisome proliferator activated receptor (PPAR)-agonist.
Results : A marked increase in urinary albumin excretion and glomerular volume was observed in
diabetic rats. Renal angiopoietin-2 and Tie-2 receptor expression were significantly higher in diabetic
rats than in the control groups, with a significant reduction in renal angiopoietin-2 expression, albuminuria, and renal hypertrophy in angiotensin II receptor blocker-treated diabetic rats. And there was a significant reduction in renal Tie-2 expression and renal hypertrophy in α-lipoic acid-treated and PPAR-γ agonist-treated diabetic rats.
Conclusion : These results demonstrate that the dysregulation of angiopoietins and Tie-2 receptor can lead to renal hypertrophy and albuminuria. Angiotensin II receptor blocker, α-lipoic acid, and PPAR-γ agonist attenuated these changes in angiopoietins and/or Tie-2 expression and prevented the development of albuminuria and renal hypertrophy in vivo.
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KEYWORD
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Angiopoietin-1, Angiopoietin-2, Diabetic nephropathy, Nephrin, Tie-2 receptor
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